Found 25 matching trials
Dabrafenib/Trametinib, BRAF or BRAF AND MEK Pre-op With BRAF and MEK Post-op, Phase IIB, Melanoma With Brain Mets,Biomarkers and Metabolites PHASE2 This is a global, multi-centre, open-label, study of GSK2118436 conducted i...
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GSK Investigational Site
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An Open Label Study to Examine the Effects of a High-Fat Meal and Particle Size on the Pharmacokinetics of Orally Administered GSK2118436 in Subjects With BRAF Mutation Positive Tumor PHASE1 The study is designed to evaluate the effects of a high fat meal on the pha...
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GSK Investigational Site
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Pharmacokinetics of Repeat Oral Doses of Dabrafenib and the Combination of Dabrafenib and Trametinib in Chinese Subjects With Melanoma PHASE1 Present clinical study will be conducted in China to evaluate the pharmacok...
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Multiple Locations
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Effects of Dabrafenib on the Single Dose Pharmacokinetics (PK) of Rosuvastatin and Midazolam PHASE1 This is an open-label, multi-center, fixed sequence study in subjects with ...
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GSK Investigational Site
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Treatment of BRAF ( B-Rapidly Accelerated Fibrosarcoma) Mutated Papillary Craniopharyngioma PHASE2 Subjects with papillary craniopharyngioma harboring a BRAF mutation will be...
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Department of Endocrinology
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Dabrafenib With Trametinib in the Adjuvant Treatment of High-risk BRAF V600 Mutation-positive Melanoma (COMBI-AD). PHASE3 This was a two-arm, randomized, double-blind Phase III study of dabrafenib ...
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Novartis Investigative Site
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Study to Evaluate Treatment of Dabrafenib Plus Trametinib in Subjects With BRAF Mutation-Positive Melanoma That Has Metastasized to the Brain PHASE2 This is a multi-cohort, open label, Phase II study with Dabrafenib (GSK2118...
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Novartis Investigative Site
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E6201 Plus Dabrafenib for the Treatment of Metastatic Melanoma Central Nervous System Metastases (CNS) PHASE1 This is a Phase 1 study of E6201 plus dabrafenib for the treatment of CNS m...
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University of Arizona Cancer Center
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Enhancing Radioiodine Incorporation Into Radio Iodine Refractory Thyroid Cancers With MAPK Inhibition PHASE2 This is a prospective interventional trial that aims to restore iodine inco...
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A Study to Evaluate the Effect of Repeat Oral Dosing of GSK2118436 on Cardiac Repolarization in Subjects With V600 BRAF Mutation-Positive Tumors PHASE1 This is a Phase I, multicenter, 2-part study with Part 1 designed as a safe...
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GSK Investigational Site
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